Tehran University of Medical Sciences Journal of Medical Bacteriology 2251-8649 11 5-6 2023 11 26 49 69 Mansoor Khaledi Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran. Fatemeh Sameni Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran. Hossein Amini-Khoei Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran Mehran Bakhtiari Students Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. Najmeh Sedighimehr Department of Physical Therapy, School of Rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran. Javad Fathi Shiraz university of medical sciences Maede Ghiyasvand Department of Biology, Shahed University, Tehran, Iran Zahra Mottaghiyan Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran. Saina Najafi Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Pouneh Mohammadpour Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran. Zahra Shirzazd Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran. Azam Haghighatfard Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Majid Validi Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahrekord University of Medical Sciences, Shahrekord. 2023 08 31 2023 11 02 Background:      The outbreak of Coronavirus Disease 2019 (COVID-19) has originated from Wuhan, China and rapidly spread all over the world. This disease is caused by a coronavirus termed Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) that mainly infects the human respiratory tract. Herbal agents including Atractylodes lancea, Ephedra, Curcumin, and Echinacea purpurea had immunomodulatory effects and antiviral activities on other respiratory viruses including Influenza virus. They strengthen the innate immunity through increasing the phagocytic activity and anti-inflammatory activity. These herbs could be used as a complementary therapy to prevent entry of COVID-19 and improve immune system.  This review delves into the role and therapeutic compounds of various herbal agents in relation to immunity, their effectiveness in treating other viral respiratory illnesses, and their potential influence on COVID-19 disease. https://jmb.tums.ac.ir/index.php/jmb/article/view/497