Tehran University of Medical Sciences Journal of Medical Bacteriology 2251-8649 2 3-4 2015 10 12 56 61 EN Samaneh Saed Antimicrobial Resistance Research Center, Buali Research Institute, Department of Microbiology and Virology, Medical School, Mashhad University of Medical Sciences, Mashhad, IR Iran. Malektaj Yazdanpanah Ghaem University Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran. Mitra Lal-Dehghani Ghaem University Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran. AmirReza Khalighi Ghaem University Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran. Mahbubeh Honarmand Ghaem University Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran. Parviz Afrough Department of Bacteriology, Medical University of Alborz, Alborz, IR Iran. Kiarash Ghazvini Antimicrobial Resistance Research Center, Buali Research Institute, Department of Microbiology and Virology, Medical School, Mashhad University of Medical Sciences, Mashhad, IR Iran. 2015 10 12 2015 10 12 Background: Acinetobacter spp. emerged as an opportunistic pathogen for hospital-acquired infections. Recently, increasing antibiotic resistance among Acinetobacter spp. has worsened the problem. The aim of this study was to investigate  the  emerging  trend  of  infection  due  to Acinetobacter  in Ghaem University Hospital, Mashhad during 2006-2012. Methods: The demographic data and information about redisposing factors was collected. Appropriate bacteriological samples were collected and Acinetobacter spp. was isolated. Antibiotics susceptibility pattern of these isolates against different antimicrobials agents was determined. Results: Results confirmed that Acinetobacter spp. cause 20.9% of nosocomial infection during this period. The trend of Acinetobacter nosocomial infection was increasing and patients with risk factors such as COPD, bronchectasia, diabetes   mellitus   were   more   prone   to   infection.  There   was   significant association   between   these   infections   and   invasive   procedures   such   as catheterization, mechanical ventilation and broad-spectrum antibiotics usage. Conclusion:  Understanding  trends  in  causative  organisms  of  nosocomial infection can help us to better define our infection control policy. https://jmb.tums.ac.ir/index.php/jmb/article/view/52 https://jmb.tums.ac.ir/index.php/jmb/article/download/52/47