Tehran University of Medical Sciences Journal of Medical Bacteriology 2251-8649 13 1 2025 02 25 69 83 Leila Shafiee Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Sajedeh Yousefinodeh Department of Biology, Shandiz Institute of higher education Mashhad, Iran Dorna Asadi Department of microbiology ,Faculty of Basic sciences, Kazerun Branch,Islamic Azad University ,Kazerun ,Iran Nafiseh Salehi Kakhki Department of biology, Islamic Azad University Mashhad Branch, Iran Ali Alnaqeeb Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Yalda Malekzadegan Department of Microbiology and Parasitology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran. Faezeh Ariamanesh Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Atefeh Kamali Faculty of Basic Sciences, Islamic Azad University, Kerman Branch, and Medicinal Plants Research Center, Zabol University of Medical Sciences Mehrab Oldin Hajarzadeh Medical student, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Zohreh Sadeghi Department of Medical Microbiology, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran. Afsane Mirshekari Department of Pediatrics Gastroenterology School of Medicine Amir al momenin Hospital Zabol University of Medical Sciences, Iran 2024 09 19 2024 10 29 This review thoroughly investigates the antimicrobial properties of medicinal plants against Helicobacter pylori (H. pylori) and highlights their potential to address the issue of drug resistance. The review highlights the significance of exploring compounds derived from plants that can efficiently suppress bacterial growth through distinct mechanisms, and it also examines the combined effects of using multiple compounds from plant extracts. The rising antibiotic resistance of H. pylori has sparked increased interest in alternative treatments, including medicinal plants, which may offer effective and safer methods for preventing and managing diseases caused by this bacterium. Currently, there is heightened interest in medicinal plants due to their lower side effects, ease of use, availability, and generally lower cost. In summary, in light of the escalating antibiotic resistance of H. pylori, this study explores the inhibitory effects of medicinal plants on this pathogen. The study underscores the vital importance of herbal medicines in tackling resistant strains of H. pylori and emphasizes the need for additional research to create new treatment strategies. https://jmb.tums.ac.ir/index.php/jmb/article/view/535