Methicillin-Resistant Staphylococcus aureus Using Broth Micro Dilution Method in Iran: A Meta-Analysis (2007-2016)

  • Ghobad Moradi Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Seyyede Maryam Bechashk Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Nader Esmailnasab Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Behzad Mohsenpour Department of infectious Disease, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  • Rashid Ramazanzadeh Cellular and Molecular Research Center and Microbiology Department, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  • Daem Roshani Department of Epidemiology and Biostatistics, Medical School, Kurdistan University of Sciences, Sanandaj, Iran.
  • Ebrahim Ghaderi Department of Epidemiology and Biostatistics, Medical School, Kurdistan University of Sciences, Sanandaj, Iran.
Keywords: Antimicrobial resistance (AMR), Iran, Methicillin-resistant Staphylococcus aureus, Methicillin, MRSA, Staphylococcus aureus


Background:      Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most signifuicant pathogens in Iran; it is one of the WHO-declared microbial resistance emergencies; and also one of the most important challenges facing the prevalence of resistance. The aim of this study was to detect MRSA using Broth Micro Dilution method and meta-analysis in Iran from 2007 to 2016. Methods:       Persian databases (including Magiran, Irandoc, and SID) and International databases (including pubmed, science direct, and scopus) were searched during this period (2007-2016), such that the high heterogeneity (50% < I2) in this study was analyzed using the DerSimonian Laird method. Data were categorized into subgroups based on year of study and province. Due to the high validity of the diagnosis of organisms and quantitative results, antimicrobial susceptibility test (AST) was used to detect MRSA. Data analysis was performed using statsdirect software. Results:      Based on the available data in medical databases, 678 articles were selected. In total, 29 remaining studies entered the meta-analysis phase. In this study, the overall prevalence of MRSA using MIC is 53% (95% CI: 0.42.31, 63.90); in 2016 it was 77.56% (95% CI: 76.07, 78.99) and in 2007 was 57.49% (95% CI: 53.17, 61.72). The heterogeneity was estimated to be 98.5% (95% CI: 98.4, 98.6). Conclusion:    Based on the results, there is an increasing prevalence of MRSA in Iran. These may be due to the failure or lack of infection control activities and antimicrobial selection pressure.


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How to Cite
Moradi G, Bechashk SM, Esmailnasab N, Mohsenpour B, Ramazanzadeh R, Roshani D, Ghaderi E. Methicillin-Resistant Staphylococcus aureus Using Broth Micro Dilution Method in Iran: A Meta-Analysis (2007-2016). jmb. 7(3-4):17-9.
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