Evaluation of Antimicrobial Re sistance of New Cases of Pulmonary Tuberculosis, in Khorasan, Iran
Abstract
Background: Multi drug-resistant Mycobacterium tuberculosis (MDR-TB) is an infection with a causative bacillus which is resistant to at least two drugs, isoniazid and rifampin. The purpose of this study is to evaluate the prevalence of TB resistance to first-line drugs of newly diagnosed active pulmonary tuberculosis.Methods: This cross-sectional study was performed on 77 patients with newly diagnosed active pulmonary tuberculosis (according to national protocols of TB). Sputum samples were cultured and antibiogram for isoniazid, rifampin, pyrazinamide, ethambutol, and Streptomycin were performed on the positive cultures.
Results: From 77 patients with tuberculosis, 48 cases have positive sputum culture. Antibiogram was done by proportional standard method and all samples were found to be fully sensitive to all first-line TB drugs.
Conclusions: According to the results of this study, the primary resistance was low to the first-line drugs for pulmonary tuberculosis of the samples collected from Khorasan, an east province of Iran. The data showed that in all patients with active pulmonary tuberculosis who were diagnosed with Ziehl–Neelsen stain of sputum, the use of the first-line drugs for tuberculosis treatment is necessary and could be sufficient.
Global tuberculosis control 2009: epidemiology, strategy, financing. WHO report 2010. Geneva, World Health Organization, 2010 (WHO/HTM/TB/2010.7).
WHO Report 2011: Global tuberculosis control. Available at: http://www. ho.int/mediacentre/ factsheets/fs104/en/.
Dye C, Scheele S, Dolin P, Pathania V, Raviglione MC. Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. JAMA 1999;282(7):677-86.
Global tuberculosis control 2009:epidemiology, strategy, financing. WHO report 2009. Geneva, World Health Organization, 2009 (WHO/HTM/TB/2009 .411).
Espinal MA et al. Determinants of drug-resistant tuberculosis: analysis of 11 countries. International J Tuberculosis and Lung Dis, 2001, 5:887–893.
Global tuberculosis control 2009:epidemiology, strategy, financing. WHO report2010. Geneva, World Health Organization, 2010(WHO/HTM/TB/2010.7).
Nasehi M, Mir Haghani. L.National Directory TB. Iran, Tehran: Andishmand;1388.
Guidelines for the programmatic management of drug-resistant tuberculosis : emergency update 2008. Geneva, World Health Organization, 2008 (WHO/HTM/TB/2008.402).
Centers for disease control and prevention.TB morbidity united states, 1997; NWR Morb Mort Wkiy Rep 1998; 47 :253-57.
Burkhard Springer, Romana C. Calligaris- Maibach, Claudia Ritter and Erik C.Böttger. Tuberculosis Drug Resistance in an Area of Low Endemicity in 2004-2006:Semiquantitative Drug Susceptibility Testing and Genotyping. J Clin Microbiol, Dec. 2008, p. 4064–4067.
Abbassi A, Golalipour M. The survey of drug ressistance of TB in positive smear patient. Horizon Med Sci. 2004; 10 (1):38-41.
Crudu. V, Arnadottir. Th, Laticevschi. D,Resistance to anti-tuberculosis drugs and practices in drug susceptibility testing in Moldova, 1995–1999. Int J Tuberc Lung Dis 2003 IUATLD; 7(4):336–342.
Velayati Ali Akbar, Masjedi Mohammad Reza, Farnia Parissa, Tabarsi Payam, Ghanavi Payam, ZiaZarifi Abol Hassan, Hoffner Sven Eric. Emergence of New Forms of Totally Drug-Resistant Tuberculosis Bacilli: Super Extensively Drug-Resistant Tuberculosis or Totally Drug-Resistant Strains in Iran. Chest 2009 April; 136; 420-425.
Ndung Perpetual Wangu, Kariuki Samuel,Ng’ang’a Zipporah, Revathi Gunturu.Resistance patterns of Mycobacterium tuberculosis isolates from pulmonary tuberculosis patients in Nairobi.J Infect DevCtries 2012; 6(1):33-39.
Merza Muayad A. Farnia Parissa. Tabarsi Payam. Khazampour Mehdi. Masjedi Mohammad Reza. Velayati Ali Akbar. Anti-tuberculosis drug resistance and associated risk factors in a tertiary level TB centre in Iran: a retrospective analysis.J Infect Dev Ctries 2011; 5(7):511-519.
Kenneth A. Harris Jr. Umadevi Mukundan. James M. Musser. Barry N. Kreiswirth, and Lalitha M. K. Genetic Diversity and Evidence for Acquired Antimicrobial Resistance in Mycobacterum tuberculosis at a Large Hospital in South India. Int J Infect Dis 2000 4: 140-147.
Heydari Ali Akbar, Movaheddanesh Masood Reza, Ghazvini Kiarash. Urine PCR Evaluation to Diagnose Pulmonary Tuberclosis. Jundishapur J Microbiol.2014 March; 7(3): e9311.
| Files | ||
| Issue | Vol 3 No 1-2 (2014) | |
| Section | Original Articles | |
| Keywords | ||
| Pulmonary tuberculosis M. tuberculosis Multi-Drug Resistance | ||
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