Carbapenem-Resistance in Clinical Klebsiella pneumoniae Isolates from Iran, Review Article
-
Mahboobe Moghadam
,
Mahdis Ghavidel
,
Sara Kooti
,
Zahra Meshkat
,
Kiarash Ghazvini
,
Ehsan Arian
,
Hadi Farsiani
Abstract
Background: Because of the current limitations of therapeutic methods, the worldwide appearance and spreading of carbapenem-resistant (CR)-Klebsiella pneumoniae has made to a key concern in the healthcare system. K. pneumoniae, the most frequent Klebsiella species is the cause of human infections, classified as top three pathogens of global concern which established in 2014 WHO Global Report on Surveillance of Antimicrobial Resistance.
Methods: Embase, PubMed/Medline, Scopus, Google Scholar, Web of Sciences and Iranian databases were searched to retrieve the potentially relevant studies. In this review, we explored the prevalence of K. pneumoniae generating three universal carbapenemases (KPCs, NDMs, and OXA-48-like) by following keywords: "carbapenem resistance" and"blaKPC" and"metallo beta lactamase" and "blaNDM" and "blaOXA" and "Klebsiella pneumoniae" and Iran.
Results: After exploiting predefined inclusion and exclusion criteria, 37 articles were collected that reported prevalence of carbapenem-resistant Klebsiella pneumoniae. At finally, 20 studies reported blaNDM , 17 studies reported blaKPC, 14 studies reported blaOXA-48 and blaVIM as gene cause resistance among Klebsiella pneumoniae strains. The described resistance to carbapenem varied across different studies, ranging from 4.4% to 100%.
Conclusion: Our findings demonstrated that the high prevalence of carbapenem-resistant Klebsiella pneumoniae expresses concern over most Iranian hospitals.
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4. Kim YJ, Kim S, Kim J, et al. Tracking short-term changes in the genetic diversity and antimicrobial resistance of OXA-232-producing Klebsiella pneumoniae ST14 in clinical settings. Clin Microbiol Infect 2020; 26(1):78-86.
5. Lomonaco S, Crawford MA, Lascols C, et al. Resistome of carbapenem-and colistin-resistant Klebsiella pneumoniae clinical isolates. PloS One 2018; 13(6).
6. Benulič K, Pirš M, Couto N, et al. Whole genome sequencing characterization of Slovenian carbapenem-resistant Klebsiella pneumoniae, including OXA-48 and NDM-1 producing outbreak isolates. PloS One 2020; 15(4):0231503.
7. vanDuin D, Doi Y. The global epidemiology of carbapenemase-producing Enterobacteriaceae. Virulence 2017; 8(4):460-9.
8. Khan FA, Hellmark B, Ehricht R, et al. Related carbapenemase-producing Klebsiella isolates detected in both a hospital and associated aquatic environment in Sweden. Europ J Clin Microbiol Infect 2018; 37(12):2241-51.
9. Mezzatesta M, Gona F, Caio C, et al. Outbreak of KPC-3-producing, and colistin-resistant, Klebsiella pneumoniae infections in two Sicilian hospitals. Clin Microbiol Infect 2011; 17(9):1444-7.
10. Kilic A, Baysallar M. The first Klebsiella pneumoniae isolate co-producing OXA-48 and NDM-1 in Turkey. Anna lab med 2015; 35(3):382-3.
11. Yigit H, Queenan AM, Anderson GJ, et al. Novel carbapenem-hydrolyzing β-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother 2001; 45(4):1151-61.
12. Papp-Wallace KM, Bethel CR, Distler AM, et al. Inhibitor resistance in the KPC-2 β-lactamase, a preeminent property of this class A β-lactamase. Antimicrob Agents Chemother 2010; 54(2):890-7.
13. Chen L, Mathema B, Chavda KD, et al. Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding. Trends Microniol 2014; 22(12):686-96.
14. García-Fernández A, Villa L, Carta C, et al. Klebsiella pneumoniae ST258 producing KPC-3 identified in Italy carries novel plasmids and OmpK36/OmpK35 porin variants. Antimicrob Agents Chemother 2012; 56(4):2143-5.
15. Pitout JD, Nordmann P, Poirel L. Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance. Antimicrob Agents Chemother 2015; 59(10):5873-84.
16. Naas T, Cuzon G, Villegas MV, et al. Genetic structures at the origin of acquisition of the β-lactamase blaKPC gene. Antimicrob Agents Chemother 2008; 52(4):1257-63.
17. Chen L, Chavda KD, Melano RG, et al. Molecular survey of the dissemination of two blaKPC-harboring IncFIA plasmids in New Jersey and New York hospitals. Antimicrob Agents Chemother 2014; 58(4):2289-94.
18. Jeon JH, Lee JH, Lee JJ, et al. Structural basis for carbapenem-hydrolyzing mechanisms of carbapenemases conferring antibiotic resistance. Int J Mol Sci 2015; 16(5):9654-92.
19. Nordmann P, Poirel L. The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwide. Clin Microbiol Infect 2014; 20(9):821-30.
20. Barberino MG, CruvinelSdA, Faria C, et al. Isolation of blaNDM-producing Enterobacteriaceae in a public hospital in Salvador, Bahia, Brazil. Braz J Infect Dis 2018; 22(1):47-50.
21. Rojas LJ, Hujer AM, Rudin SD, et al. NDM-5 and OXA-181 beta-lactamases, a significant threat continues to spread in the Americas. Antimicrob Agents Chemother 2017; 61(7):00454-17.
22. Roy S, Singh AK, Viswanathan R, et al. Transmission of imipenem resistance determinants during the course of an outbreak of NDM-1 Escherichia coli in a sick newborn care unit. J Antimicrob Chemother 2011; 66(12):2773-80.
23. Jamal WY, Albert MJ, Rotimi VO. High prevalence of New Delhi metallo-β-lactamase-1 (NDM-1) producers among carbapenem-resistant Enterobacteriaceae in Kuwait. PloS One 2016; 11(3):0152638.
24. Cuzon G, Ouanich J, Gondret R, et al. Outbreak of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in France. Antimicrob Agents Chemother 2011; 55(5):2420-3.
25. Sherchan JB, Tada T, Shrestha S, et al. Emergence of clinical isolates of highly carbapenem-resistant Klebsiella pneumoniae co-harboring blaNDM-5 and blaOXA-181 or-232 in Nepal. Int J infect Dis 2020; 92:247-52.
26. Barbarini D, Russello G, Brovarone F, et al. Evaluation of carbapenem-resistant Enterobacteriaceae in an Italian setting: report from the trench. Infect Genet Evol 2015; 30:8-14.
27. Shakibaie MR, Shahcheraghi F, Hashemi A, et al. Detection of TEM, SHV and PER type extended-spectrum ß-lactamase genes among clinical strains of Pseudomonas aeruginosa isolated from burnt patients at Shafa-Hospital, Kerman, Iran. Iran J Basic Med Sci 2008; 11(2):104-11.
28. Nordmann P, Poirel L, Carrër A, et al. How to detect NDM-1 producers. J Clin Microbiol 2011; 49(2):718-21.
29. Castanheira M, Deshpande LM, Mathai D, et al. Early dissemination of NDM-1-and OXA-181-producing Enterobacteriaceae in Indian hospitals: report from the SENTRY Antimicrobial Surveillance Program, 2006-2007. Antimicrob Agents Chemother 2011; 55(3):1274-8.
30. Ong DC, Koh TH, Syahidah N, et al. Rapid detection of the bla NDM-1 gene by real-time PCR. Antimicrob Agents Chemother 2011; 66(7):1647-9.
31. Kaase M, Nordmann P, Wichelhaus TA, et al. NDM-2 carbapenemase in Acinetobacter baumannii from Egypt. Antimicrob Agents Chemother 2011; 66(6):1260-2.
32. Zhang Y, Wu N, Zhu B, et al. Establishment of loop-mediated isothermal amplification technique for rapid detection of NDM-1 gene. Chin J Biotechnol 2011; 27(8):1232-8.
33. Pajand O, Darabi N, Arab M, et al. The emergence of the hypervirulent Klebsiella pneumoniae (hvKp) strains among circulating clonal complex 147 (CC147) harbouringblaNDM/OXA-48 carbapenemases in a tertiary care center of Iran. Ann Clin Microbiol Antimicrob 2020; 19:1-9.
34. Hosseinzadeh Z, Ebrahim-Saraie HS, Sarvari J, et al. Emerge of blaNDM-1 and blaOXA-48-like harboring carbapenem-resistant Klebsiella pneumoniae isolates from hospitalized patients in southwestern Iran J Chin Med Assoc 2018; 81(6):536-40.
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| Files | ||
| Issue | Vol 10 No 3-4 (2021) | |
| Section | Review Articles | |
| Keywords | ||
| carbapenem resistance Iran Klebsiella pneumoniae oxacillinase | ||
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How to Cite
1.
Moghadam M, Ghavidel M, Kooti S, Meshkat Z, Ghazvini K, Arian E, Farsiani H. Carbapenem-Resistance in Clinical Klebsiella pneumoniae Isolates from Iran, Review Article. J Med Bacteriol. 2021;10(3-4):51-65.
