Short Communications

PIN1 as a Predictive Biomarker for H. pylori Infection–Associated Gastric Cancer


Cancer is now one of the major causes of death across the globe. Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1), has recently emerged as a critical factor in various cancers. Numerous studies have shown that PIN1 is highly expressed in several cancer types and is significantly associated with the prognosis of patients with a certain type of tumor such as gastric cancer. Meanwhile, some studies have indicated that infection with Helicobacter pylori significantly increases the risk of developing duodenal and gastric ulcer disease and gastric cancer. In this article, we propose that PIN1 can play a vital role in the prognosis of Helicobacter pylori infection-associated with peptic ulcer disease and can be effective in order to provide the best cure and the choice for treatment.
1. Winkler KE, Swenson KI, Kornbluth S, et al. Requirement of the prolyl isomerase Pin1 for the replication checkpoint. Science 2000; 287(5458):1644-7.
2. Lu KP, Zhou XZ. The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease. Nat Rev Mol Cell Biol 2007; 8(11):904-16.
3. Nakamura K, Greenwood A, Binder L, et al. Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease. Cell 2012; 149(1):232-44.
4. Tun-Kyi A, Finn G, Greenwood A, et al. Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon–mediated immunity. Nat Immunol 2011; 12(8):733-41.
5. Liou YC, Zhou XZ, Lu KP. Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. Trends Biochem Sci 2011; 36(10):501-14.
6. Wulf G, Finn G, Suizu F, et al. Phosphorylation-specific prolyl isomerization: is there an underlying theme? Nat cell Biol 2005;7(5):435-41.
7. Suizu F, Ryo A, Wulf G, et al. Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesis. Mol Cell Biol 2006;26(4):1463-79.
8. Lee TH, Chen CH, Suizu F, et al. Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function. Mol cell 2011;42(2):147-59.
9. Bao L, Kimzey A, Sauter G, et al. Prevalent overexpression of prolyl isomerase Pin1 in human cancers. Am j Pathol 2004;164(5):1727-37.
10. Shi M, Chen L, Ji J, et al. Pin1 is overexpressed and correlates with poor prognosis in gastric cancer. Cell biochem Biophys 2015; 71(2):857-64.
11. Zhang ZZ, Yu WX, Zheng M, et al. PIN1 inhibition sensitizes chemotherapy in gastric cancer cells by targeting stem cell–like traits and multiple biomarkers. Mol Cancer Ther 2020; 19(3):906-19.
12. Wroblewski LE, Peek Jr RM, et al. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin. Microbiol. Rev 2010; 23(4):713-39.
13. Díaz P, Valenzuela Valderrama M, Bravo J, et al. Helicobacter pylori and gastric cancer: adaptive cellular mechanisms involved in disease progression. Front Microb 2018;9:5.
14. Abdi E, Latifi-Navid S, Abedi Sarvestani F, et al. Emerging therapeutic targets for gastric cancer from a host-Helicobacter pylori interaction perspective. Expert Opin ther targets 2021; 25(8):685-99.
15. Khoei SG, Sadeghi H, Saidijam M. The use of exosome carrier to augmentation of Helicobacter pylori infection treatment. Stem cell investig 2020; 7:23.
16. Suerbaum S, Michetti P. Helicobacter pylori infection. NEJM 2002; 347(15):1175-86.
17. Watanabe T, Nadatani Y, Suda W, et al. Long-term persistence of gastric dysbiosis after eradication of Helicobacter pylori in patients who underwent endoscopic submucosal dissection for early gastric cancer. Gastric Cancer 2021; 24(3):710-20.
18. Tyagi N, Krishnadev O, Srinivasan N. Prediction of protein–protein interactions between Helicobacter pylori and a human host. Mol bioSyst 2009; 5(12):1630-5.
IssueVol 11 No 3-4 (2023) QRcode
SectionShort Communications
PIN1 Biomarker H. pylori Infection Cancer

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Karimi Dermani F, Sadeghi H, Samiee-Rad F, Gholamzadeh Khoei S. PIN1 as a Predictive Biomarker for H. pylori Infection–Associated Gastric Cancer. J Med Bacteriol. 2023;11(3-4):32-34.