A Prevalence and Antimicrobial Resistance Pattern of Bacterial Strains Isolated from Patients with Urinary Tract Infection in Al-Wahda Hospital in Derna City/Libya
Abstract
Background: Urinary tract infection (UTI) is One of the most prevalent infectious diseases in human, where the study aimed to identify the most uropathogen that caused UTIs ,and its the antimicrobial resistance pattern.
Methods: the samples were collected from January and December 2021 using a standard data collection form, where the patient outcome records were mined for information on the patients' gender, age, isolated organisms, and susceptibility test results, then statistical analysis was done.
Results: 266 from 463 samples were identified as S. aureus 14.3% , in addition, the antibacterial resistance rats showed that the highest resistance was against ampicillin/Sulbactam, ceftazidine, and meropenem 79%, while, the lowest was against ciprofloxacin 40%.
Conclusion: The study showed that S. aureus is the primary cause of UTIs in Derna city, as a result of consuming antibiotics randomly, which resulted in an increase in spread and resistance of S. aureus.
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11. Chieng CC, Kong Q, Liou NS. et al. The clinical implications of bacterial pathogenesis and mucosal immunity in chronic urinary tract infection. Mucosal Immunol 2023; 16(1):61–71.
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13. Nickel J, Doiron RC.An Effective Sublingual Vaccine, MV140, Safely Reduces Risk of Recurrent Urinary Tract Infection in Women. Pathogens 2023;12(3):359.
14. Tache AM, Dinu LD, Vamanu E. Novel insights on plant extracts to prevent and treat recurrent urinary tract infections. Appl Sci 2022; 12(5):2635.
15. Al-Badr A, Al-Shaikh G. Recurrent urinary tract infections management in women: A review. Sultan Qaboos Univ Med 2013; 13(3): 359-67.
16. Ahmed N, Khalid H, Mushtaq M, et al. The molecular characterization of virulence determinants and antibiotic resistance patterns in human bacterial uropathogens. Antibiotics 2022; 11(4):516.
17. Hami IA, Ibrahim KS. Incidence of methicillin-resistant staphylococcus aureus (MRSA) recovered from patients with urinary tract infections in Zakho City/Kurdistan-Iraq. Science J University of Zakho 2023; 11(1):91-7.
18. Alshaibah LHH, Al-Khafaji ZKA, Aljelehawy QHA. Evaluation of virulence factors among Staphylococcus aureus strains isolated from patients with urinary tract infection in Al-Najaf Al-Ashraf teaching hospital. Cell Mol Biomed Reports 2021; 1(2):78-87.
19. Lee JH, Kim YG, Lee J. Inhibition of Staphylococcus aureus biofilm formation and virulence factor production by petroselinic acid and other unsaturated C18 fatty acids. Microbiol Spectr 2022; 10(3):e01330-22.
20. AubaisAljelehawy QH, HadiAlshaibah LH, Abbas Al-Khafaji ZK. Evaluation of virulence factors among Staphylococcus aureus strains isolated from patients with urinary tract infection in Al-Najaf Al-Ashraf teaching hospital. CMBR 2021; 1(2): 78-87.
21. Looney AT, Redmond EJ, Davey NM, et al. Methicillin-resistant Staphylococcus aureus as auropathogen in an Irish setting. Medicine 2017, 96(14).
22. Shu’aibu ISA, Rashida S.. Evaluation of the incidence of uropathogenic bacteria among pregnant women attending antenatal clinic Doma Hospital Gombe. Bima J. Sci. Technol 2022; 6(03):129-35.
23. Bin-Hameed EA. Phenotypic profile and multi-drug resistance of biofilm producing Staphylococcus aureus and Escherichia coli. Enhanced knowledge in sciences and technology 2022; 2(2):450-58.
24. Bryce A, Hay AD, Lane IF. Global prevalence of antibiotic resistance in paediatric urinary tract infections caused by Escherichia coli and association with routine use of antibiotics in primary care: systematic review and meta-analysis BMJ 2016; 352.
25. Choubey, S., & Verma, M. Common cause of UTI and its regimen a review paper. J Adv Microbiol Res 2022; 3(2):83-6.
26. Duicu C, Cozea I, Delean D. Antibiotic resistance patterns of urinary tract pathogens in children from Central Romania. Exp Ther Med 2021, 22(1):1-7.
27. Al-Muaala MN, Sadeq Yasir Al-Ethari A, Abdul Ameer Al-Kraety I, et al. Molecular detection of clumping factor a gene and antibiotic susceptibility evaluation of Staphylococcus aureus isolated from urinary tract infections. Archives of Razi Institute 2022; 77(2):573-78.
28. Selim S, Faried OA, Almuhayawi MS, et al. Incidence of vancomycin-resistant Staphylococcus aureus strains among patients with urinary tract infections. Antibiotics 2022; 11(3):408.
29. Mohammed MA, Alnour TM, Shakurfo OM. Prevalence and antimicrobial resistance pattern of bacterial strains isolated from patients with urinary tract infection in Messalata Central Hospital, Libya. Asian Pac J Trop Med 2016; 9(8):771-76.
30. Abulreesh HH, Organji SR, Osman GE, et al. Prevalence of antibiotic resistance and virulence factors encoding genes in clinical Staphylococcus aureus isolates in Saudi Arabia. CEGH 2017; 5(4):196-202.
31. Alhamadani YST, Oudah AS. Study of the bacterial sensitivity to different antibiotics which are isolated from patients with UTI using Kirby-Bauer Method. J Biomed Biochem 2022; 1(2):1-6.
32. La Vecchia A, Ippolito G, Taccani V, et al. Epidemiology and antimicrobial susceptibility of Staphylococcus aureus in children in a tertiary care pediatric hospital in Milan, Italy, 2017-2021. Ital J Pediatr 2022; 48(1):67.
2. Tayebi Z, Seyedjavadi SS, Goudarzi M, et al. Frequency and antibiotic resistance pattern in gram positive uropathogenes isolated from hospitalized patients with urinary tract infection in Tehran. J Genes Microb Immun 2014;1-9.
3. Gonzalez CM, Schaeffer AJ. Treatment of urinary tract infection: what's old, what's new, and what works. World j Urol 1999, 17;372-82.
4. Djawadi B, Heidari N, Mohseni M. UTI Caused by Staphylococcus saprophyticus.
5. Nerurkar A, Solanky P, Naik SS. Bacterial pathogens in urinary tract infection and antibiotic susceptibility pattern. JPBS 2012; 21(21).
6. Li R Leslie SW. Cystitis. [Updated 2023 Jan 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/ NBK482435/
7. Al-Badr A, Al-Shaikh G. Recurrent urinary tract infections management in women: a review. Sultan Qaboos Univ Med J 2013; 13(3):359.
8. Ashur AB, El Magrahi H, Elkammoshi A, et al. Prevalence and antibiotics susceptibility pattern of urine bacterial isolates from Tripoli Medical Center (TMC), Tripoli, Libya. Iberoamerican Journal of Medicine 2021; 3(3):221-6.
9. Bono MJ, Leslie SW, Reygaert WC. Urinary tract infection. In StatPearls [Internet]. StatPearls Publishing. 2022.
10. Kibret M, Abera B. Prevalence and antibiogram of bacterial isolates from urinary tract infections at Dessie Health Research Laboratory, Ethiopia. Asian Pac J Trop Biomed 2014;4(2):164-8.
11. Chieng CC, Kong Q, Liou NS. et al. The clinical implications of bacterial pathogenesis and mucosal immunity in chronic urinary tract infection. Mucosal Immunol 2023; 16(1):61–71.
12. Tahir S, Ahsan T, Tahir SA, et al. Antimicrobial multi drug resistance in urinary tract infection. IJAHS 2021;4(1):10-16..
13. Nickel J, Doiron RC.An Effective Sublingual Vaccine, MV140, Safely Reduces Risk of Recurrent Urinary Tract Infection in Women. Pathogens 2023;12(3):359.
14. Tache AM, Dinu LD, Vamanu E. Novel insights on plant extracts to prevent and treat recurrent urinary tract infections. Appl Sci 2022; 12(5):2635.
15. Al-Badr A, Al-Shaikh G. Recurrent urinary tract infections management in women: A review. Sultan Qaboos Univ Med 2013; 13(3): 359-67.
16. Ahmed N, Khalid H, Mushtaq M, et al. The molecular characterization of virulence determinants and antibiotic resistance patterns in human bacterial uropathogens. Antibiotics 2022; 11(4):516.
17. Hami IA, Ibrahim KS. Incidence of methicillin-resistant staphylococcus aureus (MRSA) recovered from patients with urinary tract infections in Zakho City/Kurdistan-Iraq. Science J University of Zakho 2023; 11(1):91-7.
18. Alshaibah LHH, Al-Khafaji ZKA, Aljelehawy QHA. Evaluation of virulence factors among Staphylococcus aureus strains isolated from patients with urinary tract infection in Al-Najaf Al-Ashraf teaching hospital. Cell Mol Biomed Reports 2021; 1(2):78-87.
19. Lee JH, Kim YG, Lee J. Inhibition of Staphylococcus aureus biofilm formation and virulence factor production by petroselinic acid and other unsaturated C18 fatty acids. Microbiol Spectr 2022; 10(3):e01330-22.
20. AubaisAljelehawy QH, HadiAlshaibah LH, Abbas Al-Khafaji ZK. Evaluation of virulence factors among Staphylococcus aureus strains isolated from patients with urinary tract infection in Al-Najaf Al-Ashraf teaching hospital. CMBR 2021; 1(2): 78-87.
21. Looney AT, Redmond EJ, Davey NM, et al. Methicillin-resistant Staphylococcus aureus as auropathogen in an Irish setting. Medicine 2017, 96(14).
22. Shu’aibu ISA, Rashida S.. Evaluation of the incidence of uropathogenic bacteria among pregnant women attending antenatal clinic Doma Hospital Gombe. Bima J. Sci. Technol 2022; 6(03):129-35.
23. Bin-Hameed EA. Phenotypic profile and multi-drug resistance of biofilm producing Staphylococcus aureus and Escherichia coli. Enhanced knowledge in sciences and technology 2022; 2(2):450-58.
24. Bryce A, Hay AD, Lane IF. Global prevalence of antibiotic resistance in paediatric urinary tract infections caused by Escherichia coli and association with routine use of antibiotics in primary care: systematic review and meta-analysis BMJ 2016; 352.
25. Choubey, S., & Verma, M. Common cause of UTI and its regimen a review paper. J Adv Microbiol Res 2022; 3(2):83-6.
26. Duicu C, Cozea I, Delean D. Antibiotic resistance patterns of urinary tract pathogens in children from Central Romania. Exp Ther Med 2021, 22(1):1-7.
27. Al-Muaala MN, Sadeq Yasir Al-Ethari A, Abdul Ameer Al-Kraety I, et al. Molecular detection of clumping factor a gene and antibiotic susceptibility evaluation of Staphylococcus aureus isolated from urinary tract infections. Archives of Razi Institute 2022; 77(2):573-78.
28. Selim S, Faried OA, Almuhayawi MS, et al. Incidence of vancomycin-resistant Staphylococcus aureus strains among patients with urinary tract infections. Antibiotics 2022; 11(3):408.
29. Mohammed MA, Alnour TM, Shakurfo OM. Prevalence and antimicrobial resistance pattern of bacterial strains isolated from patients with urinary tract infection in Messalata Central Hospital, Libya. Asian Pac J Trop Med 2016; 9(8):771-76.
30. Abulreesh HH, Organji SR, Osman GE, et al. Prevalence of antibiotic resistance and virulence factors encoding genes in clinical Staphylococcus aureus isolates in Saudi Arabia. CEGH 2017; 5(4):196-202.
31. Alhamadani YST, Oudah AS. Study of the bacterial sensitivity to different antibiotics which are isolated from patients with UTI using Kirby-Bauer Method. J Biomed Biochem 2022; 1(2):1-6.
32. La Vecchia A, Ippolito G, Taccani V, et al. Epidemiology and antimicrobial susceptibility of Staphylococcus aureus in children in a tertiary care pediatric hospital in Milan, Italy, 2017-2021. Ital J Pediatr 2022; 48(1):67.
| Files | ||
| Issue | Vol 11 No 3-4 (2023) | |
| Section | Original Articles | |
| DOI | https://doi.org/10.18502/jmb.v11i3-4.14365 | |
| Keywords | ||
| Antimicrobial Resistance S. aureus Urinary Tract Infection Uti | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Abukhatriyah A. A Prevalence and Antimicrobial Resistance Pattern of Bacterial Strains Isolated from Patients with Urinary Tract Infection in Al-Wahda Hospital in Derna City/Libya. J Med Bacteriol. 2023;11(3-4):10-17.
