Inflammatory Parameters in UTIs Infection Caused by E. coli in Diabetic Patients
Abstract
Background: Urinary tract infections (UTIs) are a public health concern, mainly for diabetic infections, who are more susceptible due to weakened immunity and high blood sugar. Understanding the role of immune parameters can help improved diagnose and attendant more effective treatment for diabetic mellitus patients with UTIs. This study aims to estimate the serum levels of AGEs, SAA, PCT, CD23 and CD25 in UTIs caused by E. coli in Diabetic Patients.
Methods: This study had been included 300 samples (blood for Inflammatory parameters and urine for bacterial diagnosis) obtained from Diabetic patients found in Al-Betool Teaching Hospital. And Baquba Teaching Hospital between June 2023 and August 2024. Urine and blood samples were collected from 300 individuals with diabetes mellitus with both type who were suspected of having UTIs. Serum was isolated from the blood, blood glucose and HBA1c test was completed to check the presence of the diabetic illnesses. The serum samples were then stored for used in measuring immunological parameters that includes AGEs, SSA, PCT, CD23 and CD25 that done later by ELISA. Urine samples were culture on the blood agar and MacConkey agar, and then Bacteria diagnoses was done by using an automatic VITEK 2 system.
Results: The current study showed that 220 samples urinary tract infections, 180 of which were bacterial. Of the 180 samples, 116 have E. coli bacterial isolates and 46 have other bacterial species. The study also shown an increase in the concentration of AGEs, SAA, PCT, CD23 and CD25 in the serum of Diabetic Mellitus patients have UTIs compared with the healthy.
Conclusion: These inflammatory markers not only serve as diagnostic tools but also help in understanding the complex immune dysfunction present in diabetic patients with UTIs caused by E. coli.
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| Issue | Vol 13 No 3 (2025) | |
| Section | Original Articles | |
| Keywords | ||
| E. coli ELISA Inflammatory Markers UTIs VITEK system. | ||
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