Case Reports

Listeria grayi meningitis in a polypathological patient: A case report

Abstract

Background:   The various species of the Listeria genus are frequently isolated from food and drink products. They are classified into two categories according to their pathogenicity. Pathogenic species are frequently incriminated in infections of the elderly, immunocompromised and pregnant women. The Listeria grayi species is rarely isolated as a pathogen in human pathologies. We report a case of L. grayi meningitis in a polypathological patient. Antimicrobial susceptibility testing revealed resistance to ampicillin and susceptibility to Meropenem. Therapeutic failure was recorded despite in vitro sensitivity.
Methods:   Conventional biochemical test and Api Listeria gallery was used for identification of the isolate.
Results:   We report a case of L. grayi meningitis in a polypathological patient.  Antimicrobial susceptibility testing revealed resistance to ampicillin and susceptibility to Meropenem. Therapeutic failure was recorded despite in vitro sensitivity.
Conclusion:   Given its infrequent reporting, Listeria grayi meningitis warrants consideration, especially in elderly patients with multiple pathologies. 

1. Jones C. Cervical cancer is herpes simplex virus 2a cofactore. Cli Micro Rev 1996; 8:549:556-661.
2. Abu Mraheil M, Barbuddhe S, Hain T, et al. Listeria. In: Rosenberg E, DeLong EF, Lory S, Stackebrandt E, Thompson F, eds. The Prokaryotes. Springer Berlin Heidelberg: Berlin, Heidelberg 2013; 219-35.
3. Skandamis PN: Listeria monocytogenes. In: Encyclopedia of Dairy Sciences. Elsevier; 2022. 305-12.
4. Troxler R, von Graevenitz A, Funke G, et al. Natural antibiotic susceptibility of Listeria species: L. grayi, L. innocua, L. ivanovii, L. monocytogenes, L. seeligeri and L. welshimeri strains. Clin Microbiol Infect 2000; 6:525-35.
5. Charlier C, Perrodeau É, Leclercq A, et al. Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study. Lancet Infect Dis 2017; 17:510-9.
6. Charlier C, Poirée S, Delavaud C, et al. Imaging of human neurolisteriosis: A prospective study of 71 cases. Clin Infect Dis 2018; 67:1419-26.
7. El Hag MMA, El Zubeir IEM, Mustafa NEM. Prevalence of Listeria species in dairy farms in Khartoum State (Sudan). Food Control 2021; 123:107699.
8. van de Beek D, de Gans J, Spanjaard L, et al. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 2004; 351:1849-59.
9. Pagliano P, Attanasio V, Rossi M, et al.: Listeria monocytogenes meningitis in the elderly: Distinctive characteristics of the clinical and laboratory presentation. J Infect 2015; 71:134-6.
10. Vásquez Alva R, Biminchumo-Sagastegui C, Villarreal-Hifume CY, et al. Listeria monocytogenes meningitis in elderly patient. Rev Fac Med Humana 2020; 20:503-7.
11. Pagliano P, Arslan F, Ascione T. Epidemiology and treatment of the commonest form of listeriosis: meningitis and bacteraemia. 7.
12. Mylonakis E, Hohmann EL, Calderwood SB. Central Nervous System Infection with Listeria monocytogenes: 33 Yearsʼ experience at a general hospital and review of 776 episodes from the literature. Medicine (Baltimore) 1998; 77:313-36.
13. Moellering RC, Medoff G, Leech I, et al. Antibiotic Synergism Against Listeria monocytogenes. Antimicrob Agents Chemother 1972; 1:30-4.
14. Azimi PH, Koranyi K, Lindsey KD. Listeria monocytogenes: synergistic effects of ampicillin and gentamicin. Am J Clin Pathol 1979; 72:974-7.
15. Temple ME, Nahata MC: Treatment of Listeriosis. Ann Pharmacother 2000; 34:656-61.
16. Rapose A, Lick SD, Ismail N. Listeria grayi bacteremia in a heart transplant recipient. Transpl Infect Dis 2008: 10:434-6.
17. Thønnings S, Knudsen JD, Schønheyder HC, et al. Antibiotic treatment and mortality in patients with Listeria monocytogenes meningitis or bacteraemia. Clin Microbiol Infect 2016: 22:725-30.
18. Stepanović S, Lazarević G, Ješić M, Koš R: Meropenem therapy failure in Listeria monocytogenes infection. Eur J Clin Microbiol Infect Dis 2004; 23:484-6.
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IssueVol 12 No 3 (2024) QRcode
SectionCase Reports
DOI https://doi.org/10.18502/jmb.v12i3.16611
Keywords
Listeria grayi Meningitis Meropenem Penicillin Polypathological patient.
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How to Cite
1.
Issa Moussa R, Habboubat I, Ben Lahlou Y, Chadli M. Listeria grayi meningitis in a polypathological patient: A case report. J Med Bacteriol. 2024;12(3):62-67.