Editorial

Aptamer Biosensors: Rapid Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Detection Solution

Rapid Detection of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus by Aptamer Biosensors

Abstract

Vancomycin is an essential glycopeptide antibiotic facing challenges from resistant bacterial strains such as vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA). Timely and precise identification of these strains is vital for efficient infection control. This report explores using aptamer-based biosensors as a novel solution for the rapid detection of hVISA. Aptamers, short, single-stranded nucleic acids, exhibit remarkable specificity and strong affinity for their targets, making them outstanding candidates for biosensor creation. These biosensors offer affordability, ease of customization, and swift performance, making them highly appropriate for medical settings. By utilizing electrochemical detection techniques, aptamer-based biosensors facilitate real-time tracking of vancomycin concentrations and may also contribute to the efficient detection of hVISA, addressing urgent demands in infectious disease control.

1. Hemdan M, Ali MA, Doghish AS, et al. Innovations in biosensor technologies for healthcare diagnostics and therapeutic drug monitoring: applications, recent progress, and future research challenges. Sensors (Basel, Switzerland). 2024; 24(16):5143.
2. Stogios PJ, Savchenko AJPS. Molecular mechanisms of vancomycin resistance. Protein Sci 2020; 29(3):654-69.
3. Zhang S, Sun X, Chang W, et al. Systematic review and meta-analysis of the epidemiology of vancomycin-intermediate and heterogeneous vancomycin-intermediate Staphylococcus aureus isolates. PLoSOne 2015; 10(8):e0136082.
4. Hiramatsu KJT. Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistance. Lancet Infect Dis 2001; 1(3):147-55.
5. Zhang Y, Lai BS, Juhas M. Recent advances in aptamer discovery and applications. Molecules (Basel, Switzerland). 2019; 24(5):941.
6. Xu Y, Jiang X, Zhou Y, et al. Systematic evolution of ligands by exponential enrichment technologies and aptamer-based applications: recent progress and challenges in precision medicine of infectious diseases. Front Bioengineering Biotechnol 2021; 9:704077.
7. Zhou J, Rossi JJN. Aptamers as targeted therapeutics: current potential and challenges. Nat Rev Drug Discov 2017; 16(3):181-202.
8. Guo X, Wang MJC. Nutrition. Recent progress in optical and electrochemical aptasensor technologies for detection of aflatoxin B1. Crit Rev Food Sci Nutr 2024; 64(33):13093-111.
9. Lin S, Cheng X, Zhu J, et al. Wearable microneedle-based electrochemical aptamer biosensing for precision dosing of drugs with narrow therapeutic windows. Sci Adv 2022; 8(38):eabq4539.
10. Wu Y, Tehrani F, Teymourian H, et al. Microneedle aptamer-based sensors for continuous, real-time therapeutic drug monitoring. Anal Chem 2022; 94(23):8335-45.
11. Arroyo-Currás N, Somerson J, Vieira PA. Real-time measurement of small molecules directly in awake, ambulatory animals. PNAS 2017; 114(4):645-50.
12. Li H, Dauphin-Ducharme P, Ortega G, et al. Calibration-free electrochemical biosensors supporting accurate molecular measurements directly in undiluted whole blood. J Am Chem Soc 2017; 139(32):11207-13.
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IssueVol 13 No 3 (2025) QRcode
SectionEditorial
DOI https://doi.org/10.18502/jmb.v13i3.19514
Keywords
Aptamer hVISA Rapid detection Staphylococcus aureus.
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Sadeghi H, Nikkhahi F, Khanjani S, Gholamzadeh Khoei S, Maleki M, Aslanimehr M. Aptamer Biosensors: Rapid Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Detection Solution. J Med Bacteriol. 2025;13(3):115-117.